News & Insights
Combined single and macroscopic recording techniques to analyze gating mechanisms of the large conductance Ca2+ and voltage activated (BK) potassium channel.
February 22, 2013
By: Bin Wang,, Ph.D.
Nguyen NV, Gruslova A, Kosiba WA and Wang B. Combined single and macroscopic recording techniques to analyze gating mechanisms of the large conductance Ca2+ and voltage activated...
An extracellular domain of the accessory 1 subunit is required for modulating BK channel voltage sensor and gate
December 12, 2011
By: Bin Wang,, Ph.D.
Gruslova A, Semenov I and Wang B (corresponding author). (2012). An extracellular domain of the accessory beta1 subunit modulates the voltage sensor and gate of BK channels. J Gen...
BK channel beta1 subunits regulate airway contraction secondary to M2 muscarinic acetylcholine receptor mediated depolarization
March 30, 2011
By: Bin Wang,, Ph.D.
Semenov I, Wang B, Herlihy JT and Brenner R. (2011). BK channel beta1 subunits regulate airway contraction secondary to M2 muscarinic acetylcholine receptor mediated depolarization...
Hamilton Brook Smith Reynolds Obtained Patent Linked to Hollywood Film
January 29, 2010
CONCORD, MA, January 29, 2010—The film "Extraordinary Measures" starring Harrison Ford and Brendan Fraser is adapted from the book, The Cure, by Pulitzer Prize winning...
Proepileptic Effects of BK Channel Gene Mutations
December 1, 2009
By: Bin Wang,, Ph.D.
Wang B, Chen, QH, Brenner R. Proepileptic effects of BK channel gene mutations. Encyclopedia of Basic Epilepsy Research. Elsevier Press; 2009.
Mechanism of Increased BK Channel Activation from a Channel Mutation that Causes Epilepsy
February 9, 2009
By: Bin Wang,, Ph.D.
Wang B, Rothberg BS, Brenner R. (2009). Mechanism of increased BK channel activation from a channel mutation that causes epilepsy. J Gen Physiol. 133:283-94.
Hox Repertoires for Motor Neuron Diversity and Connectivity Gated by a Single Accessory Factor, FoxP1
July 25, 2008
By: Bin Wang,, Ph.D.
Dasen JS, De Camilli A, Wang B, Tucker PW, and Jessell TM. (2008). The entire Hox repertoire for motor neuron diversity and connectivity is gated by a single accessory factor, FoxP1...
Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation
July 24, 2008
By: Bin Wang,, Ph.D.
Luik RM, Wang B (co-first author), Prakriya M, Wu MM, and Lewis RS. (2008). Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation. Nature 454: 538-42....
An S6 mutation in BK channels reveals beta1 subunit effects on intrinsic and voltage-dependent gating
November 27, 2006
By: Bin Wang,, Ph.D.
Wang B and Brenner R. (2006). An S6 mutation in BK channels reveals beta1 subunit effects on intrinsic and voltage-dependent gating. J Gen Physiol. 128:731-44.
BK channel beta1-subunit regulation of calcium handling and constriction in tracheal smooth muscle
October 1, 2006
By: Bin Wang,, Ph.D.
Semenov I, Wang B, Herlihy JT and Brenner R. (2006). BK channel beta1-subunit regulation of calcium handling and constriction in tracheal smooth muscle. Am J Physiol Lung Cell Mol...
Foxp1 is an essential transcriptional regulator of B cell development
July 2, 2006
By: Bin Wang,, Ph.D.
Hui H, Wang B, Borde M, Maika S, Allred L, Tucker PW and Rao A. (2006). Foxp1 is an essential transcriptional regulator of B cell development. Nat Immunol. 7:819-26. Recommended...
Mechanism of beta4 Subunit Modulation of BK Channels
March 27, 2006
By: Bin Wang,, Ph.D.
• Wang B, Rothberg BS, Brenner R. (2006). Mechanism of beta4 subunit modulation of BK channels. J Gen Physiol. 127:449-65.