News & Insights
U.S. Patent Office Conducts Two Studies Pursuant to the America Invents Act
October 21, 2011
The U.S. Patent and Trademark Office (USPTO) is seeking comments regarding prior user rights and international patent protection for small businesses pursuant to the Leahy-Smith America...
Hamilton Brook Smith Reynolds Recognized as a Top Worldwide Trademark Firm and John L. DuPré Listed as a leading Trademark Practitioner
By: John L. DuPré
Hamilton Brook Smith Reynolds is pleased to announce that we have been named to the Worldwide Trademark Review’s WTR 1000 listing as one of the top firms for trademark matters...
New Challenges and New Opportunities in Enforcing Method of Treatment Claims
July 2011
By: Brian T. Moriarty, Deirdre E. Sanders, and Lawrence P. Cogswell III,, Ph.D.
The U.S. Supreme Court and the Federal Circuit have made and are continuing to make significant changes in the law of multi-party patent infringement – namely, induced infringement...
How the New Multi-Party Patent Infringement Rulings Will Affect Pharmaceutical Treatment Claims
By: Brian T. Moriarty, Deirdre E. Sanders, and Lawrence P. Cogswell III,, Ph.D.
The very recent and continuing focus by the U.S. Supreme Court and the Federal Circuit sitting en banc on multi-party infringement issues – namely, induced infringement and divided...
BK channel beta1 subunits regulate airway contraction secondary to M2 muscarinic acetylcholine receptor mediated depolarization
March 30, 2011
By: Bin Wang,, Ph.D.
Semenov I, Wang B, Herlihy JT and Brenner R. (2011). BK channel beta1 subunits regulate airway contraction secondary to M2 muscarinic acetylcholine receptor mediated depolarization...
Hamilton Brook Smith Reynolds Obtained Patent Linked to Hollywood Film
January 29, 2010
CONCORD, MA, January 29, 2010—The film "Extraordinary Measures" starring Harrison Ford and Brendan Fraser is adapted from the book, The Cure, by Pulitzer Prize winning...
Proepileptic Effects of BK Channel Gene Mutations
December 1, 2009
By: Bin Wang,, Ph.D.
Wang B, Chen, QH, Brenner R. Proepileptic effects of BK channel gene mutations. Encyclopedia of Basic Epilepsy Research. Elsevier Press; 2009.
Mechanism of Increased BK Channel Activation from a Channel Mutation that Causes Epilepsy
February 9, 2009
By: Bin Wang,, Ph.D.
Wang B, Rothberg BS, Brenner R. (2009). Mechanism of increased BK channel activation from a channel mutation that causes epilepsy. J Gen Physiol. 133:283-94.
Hox Repertoires for Motor Neuron Diversity and Connectivity Gated by a Single Accessory Factor, FoxP1
July 25, 2008
By: Bin Wang,, Ph.D.
Dasen JS, De Camilli A, Wang B, Tucker PW, and Jessell TM. (2008). The entire Hox repertoire for motor neuron diversity and connectivity is gated by a single accessory factor, FoxP1...
Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation
July 24, 2008
By: Bin Wang,, Ph.D.
Luik RM, Wang B (co-first author), Prakriya M, Wu MM, and Lewis RS. (2008). Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation. Nature 454: 538-42....
An S6 mutation in BK channels reveals beta1 subunit effects on intrinsic and voltage-dependent gating
November 27, 2006
By: Bin Wang,, Ph.D.
Wang B and Brenner R. (2006). An S6 mutation in BK channels reveals beta1 subunit effects on intrinsic and voltage-dependent gating. J Gen Physiol. 128:731-44.
BK channel beta1-subunit regulation of calcium handling and constriction in tracheal smooth muscle
October 1, 2006
By: Bin Wang,, Ph.D.
Semenov I, Wang B, Herlihy JT and Brenner R. (2006). BK channel beta1-subunit regulation of calcium handling and constriction in tracheal smooth muscle. Am J Physiol Lung Cell Mol...